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Image Search Results
Journal: Hepatology International
Article Title: Fibroblast growth factor inhibition by molecular-targeted agents mitigates immunosuppressive tissue microenvironment in hepatocellular carcinoma
doi: 10.1007/s12072-023-10603-z
Figure Lengend Snippet: Immune checkpoint molecules altered by MTA treatment. Representative micrographs (upper panel) and quantification (lower panel) of PD-1- and PD-L1-positive cells in VT, sorafenib, lenvatinib, VEGFR2 antibody, and regorafenib cabozantinib groups. Arrowheads represent positive cells. * p < 0.05, ** p < 0.01 vs. VT, one-way ANOVA. Data are presented as mean ± SEM. VT vehicle treatment, VEGFR2 vascular endothelial growth factor receptor 2, ns not significant, PD-1 programmed cell death-1, PD-L1 programmed cell death ligand 1
Article Snippet: The primers used were purchased from TaqMan TM (
Techniques:
Journal: Hepatology International
Article Title: Fibroblast growth factor inhibition by molecular-targeted agents mitigates immunosuppressive tissue microenvironment in hepatocellular carcinoma
doi: 10.1007/s12072-023-10603-z
Figure Lengend Snippet: Tumor immune microenvironment is altered by FGFR-1/2/3/4 inhibitor treatment. Representative micrographs (upper panel) and quantification (lower panel) of CD3-positive, CD8-positive, Granzyme B-positive, Foxp3-positive, F4/80-positive areas, Arginase-1-positive areas, CD11c-positive, NK1.1-positive, PD-1-, and PD-L1-positive cells in the VT and FGFR inhibitor groups, respectively. Arrowheads represent positive cells. * p < 0.05, ** p < 0.01 vs. VT, Student t test. Data are presented as mean ± SEM. VT vehicle treatment, FGFR fibroblast growth factor receptor, ns not significant, PD-1 programmed cell death-1, PD-L1 programmed cell death ligand 1
Article Snippet: The primers used were purchased from TaqMan TM (
Techniques:
Journal: Hepatology International
Article Title: Fibroblast growth factor inhibition by molecular-targeted agents mitigates immunosuppressive tissue microenvironment in hepatocellular carcinoma
doi: 10.1007/s12072-023-10603-z
Figure Lengend Snippet: Overview of this study. The summarized changes of TIME caused by MTAs in immune syngeneic orthotopic Hep-55.1C mouse model. Compared to the VT group, significantly upregulated/downregulated each cells in each treatment group were shown in red/blue. VT vehicle treatment, VEGFR vascular endothelial growth factor receptor, FGFR fibroblast growth factor receptor, NK natural killer, PD-L1 programmed cell death ligand 1, PD-1 programmed cell death-1
Article Snippet: The primers used were purchased from TaqMan TM (
Techniques: